Begum Kurt; Tulay Koc; Serkan Celikgun; Caglar Yildiz
Volume 25, Issue 1 , 2023
Abstract
Background: An endometrial biopsy primarily aims to determine endometrial cancer and hyperplasia with atypia at an early stage.
Objectives: This study aims to evaluate the indications, histopathological diagnoses, and the number of endometrial biopsies performed in our clinic, according to the age groups ...
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Background: An endometrial biopsy primarily aims to determine endometrial cancer and hyperplasia with atypia at an early stage.
Objectives: This study aims to evaluate the indications, histopathological diagnoses, and the number of endometrial biopsies performed in our clinic, according to the age groups of patients, in light of the literature.
Methods: A retrospective review was conducted on the file data of 4,965 patients who underwent endometrial biopsy for non-obstetric reasons between 2014-2021. The patients were divided into five groups, according to their age. Pathology diagnoses were classified as benign endometrial pathology, premalignant-malignant pathology, and insufficient for diagnosis.
Results: The most common biopsy indication was abnormal uterine bleeding (61.9%), while the most common histopathological result was benign endometrial pathologies (75.3%). Endometrial cancer was also detected in 3% of the patients. The highest diagnosis of benign endometrial pathology among age groups was 96.6% in those below 35. The comparison of age groups in the diagnosis of premalignant-malignant pathology revealed that the highest diagnosis rate was 32.1% in those 65 years and over. Furthermore, the evaluation of the relationship between indications and material adequacy showed that the highest rate of insufficient for diagnosis pathology was in the postmenopausal patient group (34.0%). Moreover, insufficient for diagnosis and endometrial surface epithelium results were highest in patients over 65 (46.7%).
Conclusion: Patients aged 55-64 and those over 65 had the highest rate of endometrial cancer and insufficient for diagnosis biopsy results. Therefore, dilation and curettage may be recommended while taking a biopsy from patients in this age group.
Sinan Soylu; Caglar Yildiz; Birkan Bozkurt; Savas Karakus; Begum Kurt; Atilla Kurt
Volume 20, Issue 3 , 2018, Pages 1-8
Abstract
Background: Incisional hernia repairs are among common abdominal wall surgeries, can be primarily required or being recon- structed using a synthetic or biological material. Objectives: This study aimed at evaluating intra-abdominal adhesions and incisional site healing after the repair of the abdominal ...
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Background: Incisional hernia repairs are among common abdominal wall surgeries, can be primarily required or being recon- structed using a synthetic or biological material. Objectives: This study aimed at evaluating intra-abdominal adhesions and incisional site healing after the repair of the abdominal wall by fresh amniotic membrane-coated polypropylene mesh in comparison to only polypropylene mesh in an experimental rat study. Methods: The study protocol was approved by the Cumhuriyet University Institutional Ethics Committee for Animal Experiments(Sivas-Turkiye, date 24/06/2015). Sixteen pregnant female Wistar-Albino rats (mean weight, 275 g) were anesthetized on the 21st day of pregnancy, and a 1-cm area of the abdominal wall was excised. The pregnancy was terminated, emerging amniotic membranes were dissected, and eight pieces of the 1-cm2 polypropylene mesh were coated with these amniotic membranes without using any suture or adhesive. The polypropylene meshes were sutured on the abdominal wall of eight rats (control group), selected by simple random sampling. For the remaining eight rats, the same procedure was applied with the amniotic membrane-coated polypropy- lene meshes (experimental group). On the 28th postoperative day, the anterior abdominal wall was opened, and intra-abdominal adhesions were assessed macroscopically by Nair’s adhesion scoring system. Strip-shaped biopsy samples were taken from incision lines for histopathological examination.Results: The experimental group had significantly less intra-abdominal adhesions (i.e., Nair’s score of 2 to 4) compared to the con- trol group (two and six rats, respectively; P = 0.046), and had significantly lower mean score for polymorphonuclear leukocyte infil- tration (P = 0.039), hyperemia (P = 0.039), and epithelialization (P = 0.039). The score for the increase in connective tissue (P = 0.018) was significantly higher in the experimental group, and the scores for edema (P = 0.590) and macrophage infiltration (P = 0.590) were similar between the two groups. Conclusions: The use of polypropylene mesh coated with fresh amniotic membrane provides the advantage of decreasing postop- erative intra-abdominal adhesions along with less inflammation and higher epithelialization after abdominal wall repair surgery.
